Original Report: Patient-Oriented, Translational Research

Waist Circumference Is Strongly Associated with Renal Resistive Index in Normoalbuminuric Patients with Type 2 Diabetes
Olga Lamacchia^a, Vincenzo Nicastro^a, Donatella Camarchio^a, Giovanni Stallone^b, Loreto Gesualdo^b, Mauro Cignarelli<sup>a

a</sup>Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, and
^bUnit of Nephrology, Department of Molecular Medicine, University of Foggia, Foggia, Italy

Address of Corresponding Author

Am J Nephrol 2008;28:54-58 (DOI: 10.1159/000109239)

  Key Words

• Albuminuria
• Chronic kidney disease
• Type 2 diabetes
• Resistive index
• Metabolic syndrome

  Abstract

Objective: Anthropometric parameters may play a role in modulating the risk of kidney dysfunction. The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients. Methods: A sample of 99 consecutively recruited patients with T2DM (76 male and 23 female) was examined. The RI was assessed by duplex Doppler sonography. Results: In univariate analysis, a significant association between the RI values and age (r = 0.507, p < 0.0001), gender (being higher in women, p = 0.002), systolic blood pressure (r = 0.285, p = 0.011), smoking habit (being lower in current smokers, p = 0.047), estimated glomerular filtration rate (r = -0.435, p < 0.0001), and intima-media thickness of the carotid arteries (r = 0.271, p = 0.020) was observed. As far as anthropometric parameters are concerned, a strong correlation between waist circumference (WC; r = 0.401, p < 0.0001), BMI (r = 0.337, p = 0.003) and RI values was found but only WC maintained a significant correlation after adjusting for several confounders (p = 0.001). Conclusions: In normoalbuminuric T2DM patients, the intrarenal hemodynamic abnormalities seem primarily associated with WC.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Mauro Cignarelli, MD
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences
University of Foggia, via Luigi Pinto
IT-71100 Foggia (Italy)
Tel. +39 0881 732 212, Fax +39 0881 733 851, E-Mail m.cignarelli@unifg.it

  Article Information

O.L. and V.N. contributed equally to this work.

Received: July 28, 2007
Accepted: August 14, 2007
Published online: September 28, 2007
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 2, Number of References : 21