Case Report

Ewing's Sarcoma as Second Malignant Neoplasm after Retinoblastoma: A Case Report
Rakesh Mittal^a, Shafika Al Awadi^a, Omar Sahar^a, A.M. Behbehani<sup>b

a</sup>Department of Medical Oncology, Hussain Maki Al Juma Centre for Specialized Surgeries, and
^bAl Bahar Eye Centre, Kuwait

Address of Corresponding Author

Med Princ Pract 2008;17:84-85 (DOI: 10.1159/000109597)

  Key Words

• Retinoblastoma
• Second malignant neoplasm
• Ewing's sarcoma

  Abstract

Objectives: To report a case of a child with the hereditary form of unilateral retinoblastoma (RB), who developed Ewing's sarcoma of the right fibula 3 years after the enucleation of the right eye. Case Presentation and Intervention: The child was diagnosed as a case of RB of the right eye at the age of 9 months. He was fully investigated and found to have locally advanced RB with bone marrow involvement (Reese-Ellsworth stage IVA). Enucleation was recommended to the family, but they refused. The patient received chemotherapy and diode laser thermotherapy in Kuwait and the UK. He had a local relapse after 11 months and subsequently underwent enucleation of the right eye. After 3 years, he was investigated for a small swelling in his right lower leg. After extensive investigations, it was reported as Ewing's sarcoma. He was treated with chemotherapy, surgery (complete excision of the fibula) and high-dose chemotherapy followed by autologous stem cell transplantation. The child is now nearly 2 years after completing the treatment and is disease free. Conclusions: This case confirms the increased risk of a second malignant neoplasm (SMN) in children with hereditary RB. These children need a very close follow-up for the early diagnosis of SMNs or even subsequent malignancies.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Dr. Rakesh Mittal
Department of Medical Oncology
Hussain Maki Al Juma Centre for Specialized Surgeries
PO Box 42262, Shuwaikh 70653 (Kuwait)
Tel. +965 483 8252, Fax +965 481 0007, E-Mail rakeshmittal55@hotmail.com

  Article Information

Received: February 17, 2007
Revised: May 1, 2007
Number of Print Pages : 2
Number of Figures : 0, Number of Tables : 0, Number of References : 12