Circulating Adipocytokines in Obese Nondiabetic Patients in Relationship with Cardiovascular Risk Factors, Anthropometry and Resting-Energy Expenditure

Vol. 51, No. 5, 2007

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Original Paper

Circulating Adipocytokines in Obese Nondiabetic Patients in Relationship with Cardiovascular Risk Factors, Anthropometry and Resting-Energy Expenditure
D.A. de Luis, M. Gonzalez Sagrado, R. Conde, R. Aller, O. Izaola, E. Romero

Institute of Endocrinology and Nutrition, Medical School and Research Support Unit, Hospital Río Hortega, University of Valladolid, Valladolid, Spain

Address of Corresponding Author

Ann Nutr Metab 2007;51:416-420 (DOI: 10.1159/000111160)

Key Words

Adipocytokines
Anthropometry
Cardiovascular risk factors
Obesity

Abstract

Background: Obesity and insulin resistance are associated with cardiovascular risk factors, including altered levels of inflammatory markers and adipocytokines. The aim of the present study was to examine the relationship between circulating adipocytokines and cardiovascular risk factors. Subjects: A population of 95 obese, nondiabetic outpatients was analyzed prospectively. A complete nutritional evaluation was performed. Results: In the multivariate analysis, with leptin as a dependent variable, only fat mass remained in the model (F = 66.6; p < 0.05), with an increase of 2.24 (95% CI 1.68-2.8) ng/ml of leptin with each 1 kg of fat mass. In a new model, with adiponectin as a dependent variable, the HDL cholesterol levels remained in the model (F = 8.46; p < 0.05), with an increase of 5.38 (95% CI 1.7-9.1) ng/ml of adiponectin with each 1 mg/dl of HDL cholesterol. In a third model, with interleukin 6 (IL-6) as a dependent variable, the resistin and C-reactive protein (CRP) levels remained in the model (F = 16.8; p < 0.01), with an increase of 0.48 (95% CI 0.27-0.85) pg/ml of IL-6 with each 1 ng/ml of resistin and an increase of 0.12 (95% CI 0.029-0.214) pg/ml with each 1 mg/dl of CRP. Conclusion: Circulating adipocytokine concentrations are associated with different cardiovascular risk factors in nondiabetic obese patients.

Author Contacts

Dr. D.A. de Luis
Institute of Endocrinology and Nutrition, Medical School, Valladolid University
C/Los perales 16, Simancas
ES-47130 Valladolid (Spain)
Tel. +34 670 560 484, Fax +34 983 331 566, E-Mail dadluis@yahoo.es

Article Information

Received: May 26, 2006
Accepted: January 2, 2007
Published online: November 20, 2007
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 6, Number of References : 23

Medline Abstract (ID 18025813)

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