On the Pathology of Experimental Hydrocephalus Induced by Artificial Increase in Endoventricular CSF Pulse Pressure

Vol. 5, No. 2, 1979

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Paper

On the Pathology of Experimental Hydrocephalus Induced by Artificial Increase in Endoventricular CSF Pulse Pressure
Concezio Di Rocco, Girolamo Di Trapani, Enrico Pettorossi, Massimo Caldarelli

Institutes of Neurosurgery, Neurology and Human Physiology, Catholic University Medical School, Rome

Address of Corresponding Author

Childs Brain 1979;5:81-95 (DOI: 10.1159/000119806)

Key Words

Pathology of experimental hydrocephalus
Communicating experimental hydrocephalus
Normal pressure hydrocephalus
Intraventricular CSF pressure

Abstract

In lambs, acute and chronic communicating hydrocephalus has been created by merely increasing the amplitude of the intraventricular cerebrospinal fluid (CSF) pulsations, leaving the mean CSF pressure unchanged. The pathologic changes occurring in this type of hydrocephalus do not differ qualitatively from those observed in obstructive hydrocephalus. Beside demonstrating a direct role of ventricular pulsations in the ventricular dilation, the observed findings indicate that an increase in mean CSF pressure is not a necessary condition for the occurrence of the hydrocephalus. Consequently, the hypothesis of abnormal high intraventricular CSF pressure oscillations at the basis of the ventricular dilation of normal pressure hydrocephalic patients, receives a significant support. Further support is provided by considering that the recorded experimental pathological lesions are quite similar to those observed in normal pressure hydrocephalic patients with patent subarachnoid CSF pathways.

Author Contacts

Dr. C. Di Rocco, Istituto di Neurochirurgia, Università Cattolica, Largo Gemelli 8, 00168 Roma (Italy)

Article Information

Published online: March 04, 2008
Number of Print Pages : 15

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