Case Report

Primary Penile Diffuse Large B Cell Lymphoma Treated by Local Excision Followed by Rituximab-Containing Chemotherapy
Ha Yeon Kim^a, Sung Yong Oh^a, Suee Lee^a, Dong Mee Lee^a, Sung-Hyun Kim^a, Hyuk-Chan Kwon^a, Sook Hee Hong^b, Jin Han Yoon^c, Hyo-Jin Kim^a

Departments of
^aInternal Medicine,
^bPathology and
^cUrology, Dong-A University College of Medicine, Busan, Korea

Address of Corresponding Author

Acta Haematol 2008;120:150-152 (DOI: 10.1159/000178146)

  Key Words

• Primary penile diffuse large B cell lymphoma
• Local excision
• Rituximab-containing chemotherapy

  Abstract

Primary penile lymphoma is rarely observed in cases of extranodal malignant lymphoma. Owing principally to its rarity, no definite treatment modality has been established. We report the case of a 42-year-old man who presented with hematuria and a painless palpable mass on the penis which had persisted for 2 months. A 1.5 × 1.4 cm round mass was detected in the shaft of the penis. Histopathological examination of the excisional biopsy revealed CD20+ diffuse large B cell lymphoma. The patient was classified as having a stage I_AE lymphoma. Because radiation often causes considerable early morbidity and later loss of function of the penis, 6 cycles of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) with rituximab were administered at 3-week intervals. After treatment, the patient showed a complete response and has maintained this status for the past 7 months. Multiple options, such as surgical amputation, radiotherapy and chemotherapy, are available for treatment of this condition. However, in order to minimize treatment-related morbidity and to maintain quality of life after treatment, combination chemotherapy including rituximab could be considered the treatment of choice after local excision.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Hyo-Jin Kim
Department of Internal Medicine, Dong-A University College of Medicine
3-1 Dongdaeshin-dong, Seo-gu
Busan 602-715 (Korea)
Tel./Fax +82 51 240 2951, E-Mail kimhj@dau.ac.kr

  Article Information

Received: May 26, 2008
Accepted after revision: June 25, 2008
Published online: November 28, 2008
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 14