Comparison of Hypotonic and Isotonic Solutions Containing Sodium Hyaluronate on the Symptomatic Treatment of Dry Eye Patients

Vol. 215, No. 2, 2001

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Comparison of Hypotonic and Isotonic Solutions Containing Sodium Hyaluronate on the Symptomatic Treatment of Dry Eye Patients
Vincenzo Papa^a, Pasquale Aragona^b, Simona Russo^a, Alessandro Di Bella^a, Pietro Russo^a, Giovanni Milazzo^a

^aMedical Department SIFI SpA, Lavinaio (Catania), and
^bInstitute of Ophthalmology, University of Messina, Italy

Address of Corresponding Author

Ophthalmologica 2001;215:124-127 (DOI: 10.1159/000050842)

Key Words

Dry eye
Sodium hyaluronate
Osmolarity

Abstract

This study was designed to compare the efficacy of two artificial tears both containing hyaluronic acid but differing in their osmolarity. A multicentric double-masked, crossover clinical trial was performed in which 158 subjects were randomized to receive either hypotonic or isotonic artificial tears up to 6 times a day. Both treatments were effective in improving signs and symptoms to a similar extent. No adverse events were reported. It was concluded that hypotonic and isotonic eye drops are comparable for the symptomatic treatment of patients suffering from dry eye syndrome.

Author Contacts

Giovanni Milazzo, MD
SIFI SpA, Medical Division
Via Ercole Patti, 36
Lavinaio 95020, Catania (Italy)
Tel. +39 095 7922111, Fax +39 095 7893451, E-Mail Giovanni_Milazzo@sifi.it

Article Information

Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 15

Medline Abstract (ID 11244343)

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