Original Paper

Trabeculectomy with Mitomycin C versus Trabeculectomy Alone for Juvenile Primary Open-Angle Glaucoma
Jen-Chia Tsai^a, Hsueh-Wen Chang^b, Chien-Neng Kao^a, Ing-Chou Lai^a, Mei-Ching Teng<sup>a

a</sup>Department of Ophthalmology, Chang Gung Memorial Hospital, and
^bDepartment of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwain, ROC

Address of Corresponding Author

Ophthalmologica 2003;217:24-30 (DOI: 10.1159/000068250)

  Key Words

• Trabeculectomy
• Mitomycin C
• Juvenile primary open-angle glaucoma
• Hypotony maculopathy

  Abstract

Purpose: We compare the intermediate-term outcome of initial trabeculectomy with adjunctive mitomycin C use versus initial trabeculectomy alone for juvenile primary open-angle glaucoma. Methods: This retrospective consecutive analysis included 44 eyes from 36 patients with juvenile primary-open angle glaucoma, all of whom underwent either initial trabeculectomy with adjunctive mitomycin C use (15 eyes) or initial trabeculectomy alone without mitomycin C use (29 eyes). We compared the success rate and complications between the two groups in a three-year follow-up period following surgery. Results: Three years subsequent to surgery, the cumulative success probability was 73% for the mitomycin C group and 68% for the control group, there being no real difference between the two groups (p = 0.89). A greater incidence of hypotony maculopathy was found amongst the mitomycin C group than was the case for the control group (20 versus 0%, respectively, p = 0.034). A lower intraocular pressure amongst the mitomycin C group was noted as compared with the control group (10.8 ± 3.0 versus 13.3 ± 3.8 mm Hg, respectively, p = 0.017) amongst the successfully treated patients. Conclusions: Despite the lower intraocular pressure level for the successfully treated patients from the trabeculectomy with mitomycin C group, and a greater incidence of resultant hypotony maculopathy for this group as compared with the trabeculectomy alone group, there appeared to be no significant difference in the cumulative success probability for this group as compared with the trabeculectomy alone group. Therefore, we caution against the use of an initial trabeculectomy with mitomycin C for juvenile primary open-angle glaucoma.

Copyright © 2003 S. Karger AG, Basel

  Author Contacts

Jen-Chia Tsai
Department of Ophthalmology, Chang Gung Memorial Hospital
123, Ta-Pei Road, Niao-Sung Hsiang
Kaohsiung County 833, Taiwan (ROC)
Tel. +886 7 7317123, Fax +886 7 7318762, E-Mail tsai4118@ms26.hinet.net

  Article Information

Received: Received: August 20, 2001
Accepted after revision: April 26, 2002
Number of Figures : 3, Number of Tables : 5, Number of References : 30