Family History of Stroke among Mexican-American and Non-Hispanic White Patients with Stroke and TIA: Implications for the Feasibility and Design of Stroke Genetics Research

Vol. 24, No. 1-2, 2005

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Original Paper

Family History of Stroke among Mexican-American and Non-Hispanic White Patients with Stroke and TIA: Implications for the Feasibility and Design of Stroke Genetics Research
Lynda D. Lisabeth^a, Sharon L.R. Kardia^b, Melinda A. Smith^a, Myriam Fornage^c, Lewis B. Morgenstern^a,b

^aStroke Program, University of Michigan Health System, Ann Arbor, Mich.,
^bDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich., and
^cInstitute of Molecular Medicine, University of Texas at Houston, Houston, Tex., USA

Address of Corresponding Author

Neuroepidemiology 2005;24:96-102 (DOI: 10.1159/000081056)

Key Words

Ethnicity
Genetics
Stroke
Family history

Abstract

Family history of stroke may differ by ethnicity. This study examined the associations of ethnicity and stroke risk factors with family history of stroke using data from the Brain Attack Surveillance in Corpus Christi Project. A random sample of stroke/transient ischemic attack cases was interviewed about family history of stroke (n = 524). Thirty-six percent of the cases reported a family history of stroke, with 26% reporting a parental and 13% a sibling history. Compared to non-Hispanic whites (NHWs), Mexican-Americans (MAs) were two times (OR = 2.07; 95% CI: 1.09-3.95) more likely to have a sibling with stroke. More MAs (8.1%; 95% CI: 4.6-11.6) had living siblings with stroke compared to NHWs (1.9%; 95% CI: 0.1-3.8). Since MAs are more likely to have living siblings with stroke compared with NHWs, MAs may be a more feasible population for family stroke studies than predominantly white populations.

Author Contacts

Lewis B. Morgenstern, MD
University of Michigan Medical School
1500 E. Medical Center Dr., TC 1920/0316
Ann Arbor, MI 48109-0316 (USA)
Tel. +1 734 615 7390, Fax +1 734 936 8763, E-Mail LMorgens@med.umich.edu

Article Information

Published online: September 24, 2004
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 22

Medline Abstract (ID 15459516)

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