Deep Brain Stimulation for Parkinson’s Disease: Association between Stimulation Parameters and Cognitive Performance

Vol. 82, No. 4, 2004

Free Abstract Article (References) Article (PDF 63 KB)

ASSFN Meeting 2003

Deep Brain Stimulation for Parkinson's Disease: Association between Stimulation Parameters and Cognitive Performance
P. Francel, K. Ryder, J. Wetmore, A. Stevens, K. Bharucha, W.W. Beatty, J. Scott

University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA

Address of Corresponding Author

Stereotact Funct Neurosurg 2004;82:191-193 (DOI: 10.1159/000082208)

Key Words

Parkinson's disease
Cognition
Neurosurgery
Deep brain stimulation

Abstract

Chronic subthalamic nucleus stimulation produces inconsistent patterns of cognitive change in Parkinson's disease patients. Individually tailored stimulation parameters may contribute to this variable pattern of change. Systematic variation of amplitude, pulse width, and rate of stimulation has been reported to produce unique changes in motor and limbic response. To evaluate the association between stimulation parameters and cognitive/behavioral response, neuropsychological performance and stimulation parameter data of 8 Parkinson's disease patients were submitted to Pearson r correlation analysis. Results indicate that each stimulation parameter was significantly associated with a subset of measures. The current findings raise the possibility that adverse cognitive/behavioral responses may be treated through parameter modification while maintaining motor symptom efficacy.

Author Contacts

Paul Francel, MD, PhD
Neurosurgery Clinic, University of Oklahoma Health Sciences Center
711, Stanton L. Young Blvd., Suite 206
Oklahoma City, OK 73104 (USA)
Tel. +1 405 271 4912, Fax +1 405 271 3091, E-Mail paul-francel@ouhsc.edu

Article Information

Published online: November 18, 2004
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 2, Number of References : 13

Medline Abstract (ID 15557768)

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