The<i> Tau</i> Gene Haplotype H1 Confers a Susceptibility to Parkinson’s Disease

Vol. 53, No. 1, 2005

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Original Paper

The Tau Gene Haplotype H1 Confers a Susceptibility to Parkinson's Disease
Jun Zhang^a, Yiqing Song^{b, c}, Honglei Chen^b, Dongsheng Fan^a

^aDepartment of Neurology, the Third Hospital of Beijing University, Beijing, China; Departments of
^bNutrition and
^cEpidemiology, Harvard School of Public Health, Boston, Mass., USA

Address of Corresponding Author

Eur Neurol 2005;53:15-21 (DOI: 10.1159/000082956)

Key Words

Tau gene
Parkinson's disease
Polymorphism
Genotype
Haplotype H1

Abstract

Background: Polymorphisms in the tau gene may be associated with increased risk for idiopathic Parkinson's disease (PD); however, most of previous association studies have been underpowered to detect a potentially modest contribution of the tau variants to PD risk. Objective: To clarify the relationship between genetic variation in tau gene and PD risk, we conducted a meta-analysis of all published association studies. We identified 14 independent case-control studies including 2,093 PD cases and 2,258 controls. After excluding two studies contributing to most of between-study heterogeneity, the pooled odds ratios (OR) and 95% confidence intervals (CI) of PD were 1.42 (95% CI, 1.23-1.65) for those with H1/H1 genotype compared with all others and 1.52 (95% CI, 1.12-2.04) for all individuals carrying H1 haplotype versus all others. Based on the data available, the results were not significantly different according to sex, family history of PD, age at onset and dementia status. Conclusions: Our results support the notion that tau gene H1 haplotype may be an important risk factor of PD.

Author Contacts

Dr. Jun Zhang
Department of Neurology
The Third Hospital of Beijing University
Beijing 100083 (China)
Tel. +86 1 1331 1298 799, Fax +86 1 6201 7700, E-Mail who626@163.com

Article Information

Received: July 19, 2004
Accepted: October 28, 2004
Published online: December 27, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 35

Medline Abstract (ID 15627775)

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