CD20-Negative Pyothorax-Associated B Cell Lymphoma

Vol. 113, No. 2, 2005

Free Abstract Article (Fulltext) Article (PDF 50 KB)

Case Report

CD20-Negative Pyothorax-Associated B Cell Lymphoma
Kenji Fukuno^a,c, Hisashi Tsurumi^c, Nobuhiro Kanemura^a, Masaru Nishio^a, Shinobu Tanabashi^a, Kiyonao Okamoto^b, Hisataka Moriwaki^c

Departments of
^aInternal Medicine and
^bPathology, Takayama Red Cross Hospital, Takayama,
^cFirst Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan

Address of Corresponding Author

Acta Haematol 2005;113:144-145 (DOI: 10.1159/000083453)

Key Words

CD20
Epstein-Barr virus
Pyothorax-associated lymphoma
THP-COP therapy
Tuberculous pleuritis

Abstract

We describe an 86-year-old male who developed CD20-negative pyothorax-associated B cell lymphoma 64 years after he had suffered from tuberculous pleuritis. Therapy with 8 courses of THP-COP at 2-week intervals was followed by involved-field radiotherapy of 30 Gy. Uncertain complete remission was achieved. Thereafter, local recurrence of pyothorax-associated lymphoma (PAL) at the primary site was seen. The patient received salvage radiotherapy of 50 Gy. The patient died of pneumonia during a second uncertain complete remission. The progression-free survival and overall survival of this patient were 10 and 15 months, respectively. When compared with the median survival of 9 months reported in the literature, the adverse effect of CD20 negativity on prognosis may not apply to PAL patients with an occasional aberrant phenotype.

Author Contacts

Hisataka Moriwaki, MD
First Department of Internal Medicine, Gifu University School of Medicine
1-1, Yanagido, Gifu 501-1194 (Japan)
Tel. +81 58 230 6308, Fax +81 58 230 6310
E-Mail hmori@cc.gifu-u.ac.jp

Article Information

Received: April 22, 2004
Accepted: May 26, 2004
Number of Print Pages : 2
Number of Figures : 0, Number of Tables : 0, Number of References : 8

Medline Abstract (ID 15802894)

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