Address of Corresponding Author

Pharmacology 2005;74:152-156 (DOI: 10.1159/000084548)

  Key Words

• Aspirin
• Acetaminophen
• TNF-
• IL-1 or IFN-
• Spinal cord

  Abstract

Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase. Acetaminophen (ACET) is also an effective analgesic and may selectively inhibit brain prostaglandin synthetase. Various proinflammatory cytokines injected into the central nervous system show pain behavior. In the present study, the effects of orally administered ASA and ACET on pain behaviors induced by various proinflammatory cytokines were examined. At a dose of 100 mg/kg, ASA or ACET did not affect the pain behavior induced by TNF- (100 pg), IL-1 (100 pg) or IFN- (100 pg) administered intrathecally. However, at doses of 200 and 300 mg/kg, ASA or ACET significantly and dose-dependently attenuated pain behavior induced by TNF-, IL-1 or IFN- administered intrathecally. Our results suggest that orally administered ASA and ACET produce antinociception by inhibiting the nociceptive action of TNF-, IL-1 or IFN- administered intrathecally.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Prof. Hong-Won Suh, PhD
Department of Pharmacology, College of Medicine
1 Okchun-dong
Chunchon, Kangwondo 200-702 (Korea)
Tel. +82 33 2482614, Fax +82 33 2482612, E-Mail hwsuh@hallym.ac.kr

  Article Information

Received: July 20, 2004
Accepted: January 25, 2005
Published online: March 17, 2005
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 24