Fluoride Dose Response in pH-Cycling Models Using Bovine Enamel

Vol. 39, No. 6, 2005

Free Abstract Article (References) Article (PDF 117 KB)

Original Paper

Fluoride Dose Response in pH-Cycling Models Using Bovine Enamel
Ana Elisa de Mello Vieira^a, Alberto Carlos Botazzo Delbem^a, Kikue Takebayashi Sassaki^a, Eliana Rodrigues^a, Jaime Aparecido Cury^b, Robson Frederico Cunha^a

^aUNESP, São Paulo State University, School of Dentistry at Araçatuba, São Paulo, and
^bUNICAMP, Campinas State University, School of Dentistry at Piracicaba, São Paulo, Brazil

Address of Corresponding Author

Caries Res 2005;39:514-520 (DOI: 10.1159/000088189)

Key Words

Fluoride effect on caries dynamics
Fluoride effect on enamel remineralization
Microhardness analysis
In vitro pH-cycling models
Bovine enamel
Topical fluoride
Fluoride solution dose-response relationship

Abstract

The aim of this study was to establish methodologies for verification of the fluoride solution dose-response relationship using bovine enamel and pH-cycling models. Six models of the cariogenic challenge were performed, varying the time of demineralization and pH, time of remineralization, composition of de- and remineralization solutions, frequency and time of application of treatment solutions and pH-cycling duration. For the evaluation of the fluoride effect on caries dynamics, two proposed models provided for improvement in standardization of methods leading to a higher level of precision, demonstrating a dose response between treatments with regard to surface microhardness and Delta Z. For the evaluation of the fluoride effect on enamel remineralization, the addition of fluoride to the de- and remineralization solutions and the reduction of frequency and time of application of fluoride solutions led to a more suitable pH-cycling model.

Author Contacts

Alberto Carlos Botazzo Delbem
Faculdade de Odontologia de Araçatuba - UNESP, Disciplina de Odontopediatria
Rua José Bonifácio 1193, Araçatuba, Cep 16015-050, SP (Brazil)
Tel. +55 18 3636 3235, Fax +55 18 3636 3332
E-Mail adelbem@terra.com.br, aemvieira@uol.com.br

Article Information

Received: July 5, 2004
Accepted after revision: February 25, 2005
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 32

Medline Abstract (ID 16251798)

Download Citation

Cited In

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.