Methadone Treatment in Clinical Practice in Italy: Need for Improvement

Vol. 12, No. 3, 2006

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Research Report

Methadone Treatment in Clinical Practice in Italy: Need for Improvement
Patrizia Schifano^a, Anna Maria Bargagli^a, Valeria Belleudi^a, Laura Amato^a, Marina Davoli^a, Roberto Diecidue^b, Elisabetta Versino^c, Federica Vigna-Taglianti^b, Fabrizio Faggiano^d, Carlo A. Perucci^a, for the VEdeTTE Study Group

^aDepartment of Epidemiology, ASL Rome E, Rome,
^bRegional Monitoring Center for Drug Addiction, Grugliasco,
^cDepartment of Public Health, University of Turin, Turin, and
^dDepartment of Medical Sciences, Avogadro University, Novara, Italy

Address of Corresponding Author

Eur Addict Res 2006;12:121-127 (DOI: 10.1159/000092113)

Key Words

Heroin treatment
Methadone maintenance
Doses, methadone
Treatment outcome, methadone
Longitudinal studies, methadone

Abstract

Background: Methadone at appropriate doses has been demonstrated to be the most effective means for retaining patients in treatment and suppressing heroin use. Aim: To describe the modalities of day-to-day provision of methadone maintenance treatments (MMT) in Italian public health centres and to analyze the duration of MMTs by dose and by association with psychosocial treatments. Patients and Methods: We analyzed 8,378 subjects, 18 years of age or over, enrolled between September 1998 and March 2001 in one of 115 public treatment centres for heroin dependence in Italy. Treatment data were collected for each subject from enrolment to the end of the study period (maximum of 18 months). Results: Of the total of 29,495 treatments delivered, 21.0% were methadone maintenance, and 34.4% were methadone detoxification. Fifty percent of MMTs offered had a mean dose less than or equal to 40 mg/day, and only 19% had doses higher than or equal to 60 mg/day; treatments with doses higher than 60 mg/day lasted longer than treatments with lower doses. Differences in treatment length were observed between MMTs associated with a psychosocial treatment and those offered alone, only for doses <60 mg/day. Conclusions: In Italy, MMTs are delivered at inappropriate doses in more than 80% of the cases. The increase of methadone doses to adequate levels as indicated by the literature is necessary to ensure proper and effective use of MMTs in public treatment centres for heroin users.

Author Contacts

Dr. Patrizia Schifano
Via di S. Costanza 53
IT-00198 Rome (Italy)
Tel. +39 06 83 060 420, Fax +39 06 83 060 463, E-Mail schifano@asplazio.it

Article Information

Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 4, Number of References : 19

Medline Abstract (ID 16778432)

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