Two Genetic Rat Models of Arterial Hypertension Show Different Mechanisms by Which Adult Hippocampal Neurogenesis Is Increased

Vol. 29, No. 1-2, 2007

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Original Paper

Two Genetic Rat Models of Arterial Hypertension Show Different Mechanisms by Which Adult Hippocampal Neurogenesis Is Increased
Golo Kronenberg^a-c, Andrea Lippoldt^a1, Gerd Kempermann^{a, b}

^aMax Delbrück Center for Molecular Medicine (MDC) Berlin-Buch,
^bVolkswagenStiftung Research Group, Department of Experimental Neurology, Charité University Medicine Berlin, and
^cDepartment of Psychiatry, Charité Campus Benjamin Franklin, Berlin, Germany

Address of Corresponding Author

Dev Neurosci 2007;29:124-133 (DOI: 10.1159/000096217)

Key Words

Rat
Attention deficit/hyperactivity disorder
Doublecortin
Stem cell
Plasticity
Hippocampus

Abstract

To investigate strain differences and genetic effects on different aspects of neurogenesis, we compared young adult spontaneously hypertensive/hyperactive rats (SHR) and stroke-prone SHR (SHRSP) with the genetic control WKY strain. In both hypertensive/hyperactive strains, the number of newly generated neurons and the number of lineage-determined cells as detected by doublecortin (DCX) immunoreactivity were significantly increased. SHRSP had significantly more DCX-positive cells than the other groups. Whereas cell proliferation as measured by Ki67 expression was increased in SHR, we found no difference between SHRSP and WKY. In summary, we found increased net neurogenesis in both hypertensive/hyperactive strains. However, this phenotype was based on different mechanisms in the course of neuronal development: cell proliferation in SHR and cell survival in SHRSP. In addition, we found that within strains the number of DCX-positive cells was not predictive of the net number of new neurons and that the increase in neurogenesis was not significantly correlated with blood pressure in SHR and WKY. However, in both SHR and SHRSP, cell proliferation showed an association with blood pressure recordings.

Author Contacts

Gerd Kempermann, MD
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Robert-Rössle-Strasse 10, DE-13125 Berlin-Buch (Germany)
Tel. +49 30 9406 2362, Fax +49 30 9406 3814
E-Mail gerd.kempermann@mdc-berlin.de

Article Information

Received: December 22, 2005
Accepted: March 28, 2006
Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 0, Number of References : 57

Medline Abstract (ID 17148955)

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