Pediatric Clinical Case Sessions

Hepatic Enzyme Abnormalities in Turner Syndrome: A Case Report
P. Pervanidou, P. Xekouki, C. Dacou-Voutetakis

First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, University of Athens, 'Aghia Sophia' Children's Hospital, Athens, Greece

Address of Corresponding Author

Horm Res 2007;67 (Suppl. 1):106-108 (DOI: 10.1159/000097563)

  Key Words

• Turner syndrome
• Hepatic enzymes
• Hormone replacement therapy
• Growth hormone
• Liver

  Abstract

Background: Liver dysfunction has been described in subjects with Turner syndrome. The mechanism involved is not known. Methods: Using appropriate methodology, we evaluated the hepatic enzymes serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and -glutamyl transpeptidase (-GT) in a girl with 45 XO/46 Xr mosaic karyotype. She was monitored from age 9 to 20 years while she underwent various therapeutic regimens. Results: Serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and particularly -GT concentrations ranged from normal to elevated values during human growth hormone therapy, estrogen replacement therapy (conjugated estrogens were replaced after 1 year with transdermal estrogens and medroxyprogesterone), and periods without therapy. The type of the therapeutic regimen did not seem to influence the hepatic enzyme values. A correlation was found between -GT values and body mass index (BMI). Conclusions: In our patient the waxing and waning of the liver enzymes was not influenced by the therapeutic regimen, but -GT seemed to correlate with BMI.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Panagiota Pervanidou, MD
University of Athens, 'Aghia Sophia' Children's Hospital
First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes
26 Charavgis Str., Athens, Chalandri 152 32 (Greece)
Tel. +30 210 683 3936, Fax +30 210 652 5013, E-Mail ppervanid@med.uoa.gr

  Article Information

Published online: February 15, 2007
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 13