Incidence of New Stroke or New Myocardial Infarction or Death at 39-Month Follow-Up in Patients with Diabetes Mellitus, Hypertension or Both with and without Microalbuminuria

Vol. 109, No. 1, 2008

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Original Research

Incidence of New Stroke or New Myocardial Infarction or Death at 39-Month Follow-Up in Patients with Diabetes Mellitus, Hypertension or Both with and without Microalbuminuria
Gautham Ravipati^a, Wilbert S. Aronow^a, Chul Ahn^b, Rose M. Alappat^a, John A. McClung^a, Melvin B. Weiss^a

^aDepartment of Medicine, Cardiology Division, New York Medical College, Valhalla, N.Y., and
^bDepartment of Medicine, University of Texas School of Medicine at Houston, Houston, Tex., USA

Address of Corresponding Author

Cardiology 2008;109:62-65 (DOI: 10.1159/000105327)

Key Words

Microalbuminuria
Hypertension
Diabetes mellitus
Left ventricular hypertrophy
Stroke
Myocardial infarction

Abstract

We investigated in 306 patients, mean age 57 ± 10 years, with diabetes mellitus (202 patients) or hypertension (179 patients) whether microalbuminuria was a significant independent risk factor for the development of new stroke or new myocardial infarction (MI) or death. At 39-month follow-up, new stroke or new MI or death developed in 44 of 111 patients (40%) with microalbuminuria and in 38 of 195 patients (19%) without microalbuminuria (p = 0.0001). Stepwise Cox regression analysis showed that significant independent predictors of the time to development of new stroke or new MI or death were (1) diabetes (risk ratio = 1.76), (2) left ventricular (LV) mass index (risk ratio = 1.020 for each 1 g/m² increase), (3) prior stroke (risk ratio = 5.39), and (4) prior MI (risk ratio = 3.29). Microalbuminuria was not a significant independent predictor of new stroke or new MI or death, but LV mass index, diabetes mellitus, prior stroke, and prior MI were significant independent predictors.

Author Contacts

Wilbert S. Aronow, MD
Cardiology Division
New York Medical College, Macy Pavilion, Room 138
Valhalla, NY 10595 (USA)
Tel. +1 914 493 5311, Fax +1 914 235 6274, E-Mail wsaronow@aol.com

Article Information

Received: October 12, 2006
Accepted after revision: December 6, 2006
Published online: July 10, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 3, Number of References : 10

Medline Abstract (ID 17627110)

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