Mini Review

Endocrine Late Effects of Childhood Cancer Therapy: A Report from the Children's Oncology Group
Radha Nandagopal^a, Caroline Laverdière^b, Daniel Mulrooney^c, Melissa M. Hudson^d, Lillian Meacham<sup>a

a</sup>Division of Pediatric Endocrinology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga., USA;
^bService of Hematology/Oncology, Sainte-Justine Hospital, University of Montreal, Montreal, Que., Canada;
^cDivision of Pediatric Hematology/Oncology/Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minnesota, Minn., and
^dDepartment of Hematology-Oncology, St. Jude Children's Research Hospital and the University of Tennessee College of Medicine, Memphis, Tenn., USA

Address of Corresponding Author

Horm Res 2008;69:65-74 (DOI: 10.1159/000111809)

  Key Words

• Endocrine late effects
• Childhood cancer
• Chemotherapy
• Radiation therapy
• Pediatrics

  Abstract

Pediatric oncologists are curing increasing numbers of patients with childhood cancer, and most children diagnosed with a malignancy may now be expected to become long-term survivors. As the number of childhood cancer survivors grows, so too does the need for evidence-based surveillance of the long-term effects of cancer therapy. Long-term effects involving the endocrine system represent a frequent complication of therapy. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers(COG LTFUG), most recently updated in 2006, provide a summary of the known endocrine late effects of surgery, radiation, chemotherapy, and stem cell transplant. This paper summarizes the scope and nature of the endocrine late effects of childhood cancer therapy based upon a review of the pertinent medical literature, and demonstrates how pediatric oncologists can use these guidelines in clinical practice.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Radha Nandagopal, MD
c/o Children's Oncology Group, Publications Office
440 E. Huntington Drive, 4th Floor
Arcadia, CA 91006 (USA)
Tel. +1 626 241 1509, Fax +1 626 445 4334, E-Mail rnandagopal@hotmail.com

  Article Information

Received: December 12, 2006
Accepted after revision: July 31, 2007
Published online: December 5, 2007
Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 4, Number of References : 46