Original Paper

A Comparative Study of Bimatoprost and Travoprost: Effect on Intraocular Pressure and Ocular Circulation in Newly Diagnosed Glaucoma Patients
Gürsoy Alagöz^a, Kamil Gürel^b, Atilla Bayer^c, Didem Serin^a, Serdal Çelebi^a, ahap Kükner^a

Departments of
^aOphthalmology and
^bRadiology, Medical Faculty, Abant Izzet Baysal University, Bolu, and
^cGülhane Military Medical Faculty, Ankara, Turkey

Address of Corresponding Author

Ophthalmologica 2008;222:88-95 (DOI: 10.1159/000112624)

  Key Words

• Travoprost
• Bimatoprost
• Intraocular pressure
• Ocular circulation

  Abstract

Background: This study compares intraocular pressure (IOP)-lowering efficacy and retrobulbar hemodynamic effects of bimatoprost and travoprost in patients with newly diagnosed open-angle glaucoma. Methods: Patients were randomly assigned to one of two treatment groups (bimatoprost group, n = 36; travoprost group, n = 46). IOP levels were measured with Goldmann applanation tonometer. Peak systolic velocity, end-diastolic velocity and resistivity index were obtained for each vessel by color Doppler imaging. Results: Both bimatoprost and travoprost significantly lowered IOP on days 30, 90 and 180 (p < 0.001). There was no significance between the 2 drugs on all follow-up visits. End-diastolic velocity of central retinal artery on day 180 was significantly higher than the value obtained at baseline in both groups. Conclusions: Patients were likely to achieve and maintain low target IOP with both drugs. Both drugs also resulted in improvement in the central retinal artery blood flow.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Dr. Gürsoy Alagöz
Abant Izzet Baysal Universitesi Tp Fak
Göz Hastalklar ABD, Gölköy
TR-14280 Bolu (Turkey)
Tel. +90 505 482 59 99, Fax +90 374 253 45 59, E-Mail gursoyalagoz@hotmail.com

  Article Information

Published online: February 22, 2008
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 4, Number of References : 42