Original Paper

Meta-Analysis of Chromovitrectomy with Indocyanine Green in Macular Hole Surgery
Eduardo B. Rodrigues^{a, b}, Carsten H. Meyer<sup>a

a</sup>Department of Ophthalmology, Philipps University Marburg, Marburg, Germany;
^bRetina Department, Ophthalmology Service, Hospital Regional Sao Jose, Instituto de Olhos Florianopolis, Florianopolis, Brazil

Address of Corresponding Author

Ophthalmologica 2008;222:123-129 (DOI: 10.1159/000112630)

  Key Words

• Indocyanine green
• Internal limiting membrane
• Macular hole
• Chromovitrectomy

  Abstract

Purpose: To report a meta-analysis of the literature comparing internal limiting membrane (ILM) peeling with and without indocyanine green (ICG) staining in macular hole (MH) treatment. Methods: A Pubmed search was conducted from January 1999 to June 2004. Manuscripts describing the anatomical and functional outcomes of vitrectomy plus ILM peeling with and without ICG application in MH surgery were reviewed. A statistical meta-analysis was performed including studies which defined anatomical outcomes as closure of the MH and disappearance of the fluid cuff and functional outcomes as improvement of 2 or more Snellen lines. A secondary outcome was to investigate the incidence of retinal pigment epithelium (RPE) alterations with and without ICG staining in MH surgery. Results: Results including all types of MHs in 837 eyes indicated the same anatomical success but worse functional outcomes in the group with ICG application (p = 0.0008; odds ratio = 0.587, 95% confidence interval = 0.427-0.808). A higher incidence of RPE alterations in the ICG injection group was observed. The incidence of RPE alterations was found to be 1.98%, whereas RPE changes were noted in 13.83% of 201 patients with ICG application (odds ratio = 7.998). Conclusion: This meta-analysis of previous reports comparing ILM peeling with and without intravitreal ICG application in the treatment of MHs demonstrated statistically worse functional outcomes when ICG was applied (p = 0.0008). A higher number of RPE alterations were observed in the ICG-stained group.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Eduardo B. Rodrigues, MD
Luiz Frederico Wagner 86 Canasvieiras
Florianópolis SC 88015-540 (Brazil)
Tel./Fax +55 48 3222 3380 E-Mail edubrodriguess@yahoo.com.br

  Article Information

Received: April 7, 2005
Accepted after revision: November 3, 2006
Published online: February 22, 2008
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 53