Inhibition of Dermal MRSA Colonization by Microalgal Micro- and Nanoparticles

Vol. 21, No. 2, 2008

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Original Paper

Inhibition of Dermal MRSA Colonization by Microalgal Micro- and Nanoparticles
G. Lukowski^a, U. Lindequist^{a, b}, S. Mundt^{a, b}, A. Kramer^c, W.-D. Jülich^{a, b}

^aInstitute of Marine Biotechnology e.V. and Institutes of
^bPharmacy and
^cHygiene and Environmental Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany

Address of Corresponding Author

Skin Pharmacol Physiol 2008;21:98-105 (DOI: 10.1159/000113066)

Key Words

Methicillin-resistant Staphylococcus aureus
Micro- and nanoparticles
Prevention of colonization
Animal skin

Abstract

The aim of this study was to investigate the prevention of the dermal colonization of methicillin-resistant Staphylococcus aureus (MRSA) strains by the application of micro- and nanoparticles called Maresome. Maresome were prepared from selected microalgae by a novel emulsion technique. They contain lipids and all other components of the microalgae in an encapsulated form. It could be shown that Maresome prepared from a cyanobacterial strain of the order Nostocales (Bio33-Maresome) were able to inhibit the dermal colonization of different MRSA strains (North German Epidemic Strain, Col, N315) and even of the vancomycin-resistant strain MU50 in the models 'mouse ear' and 'cow udder teat'. Pretreatment of the skin with Maresome reduced the number of attached MRSA by 3-4 log units in comparison to the control. We assume that a prophylactic skin care with Maresome could complete the multibarrier anti-infectious strategy against MRSA.

Author Contacts

Dr. Gerold Lukowski
Institute of Marine Biotechnology e.V.
Walter-Rathenau-Strasse 49a
DE-17489 Greifswald (Germany)
Tel. +49 3834 864 865, Fax +49 3834 864 885, E-Mail lukowski@uni-greifswald.de

Article Information

Received: December 1, 2006
Accepted after revision: September 28, 2007
Published online: January 14, 2008
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 2, Number of References : 37

Medline Abstract (ID 18198493)

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