Clinical Case · Kasuistik

Complete Response of CNS-involved Olfactory Neuroendocrine Tumor Using Multimodal Therapy
Gaurav Ahuja^a, Sandra Cuellar^b, Iffat Choudhry^c, Suman Setty^c, Mike Yao^d, Lee Villano<sup>a

a</sup> Department of Medicine,
^bDepartment of Pharmacy,
^c Department of Pathology,
^dDepartment of Otolaryngology, The University of Illinois at Chicago, USA

Address of Corresponding Author

Onkologie 2008;31:119-121 (DOI: 10.1159/000113505)

  Key Words

• Olfactory
• Sinonasal
• Neuroendocrine tumor
• Chemotherapy
• Radiation therapy

  Summary

Introduction: Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable. Case Report: We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery. Conclusion: To our knowledge, this combination treatment approach has not been reported in the literature.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

J. Lee Villano, M.D., Ph.D., University of Illinois at Chicago, Dept. of Medicine, Section of Hematology/Oncology, 909 S. Wolcott Ave. Rm. 3133 M/C 734, Chicago IL 60612, USA, Tel. +1 312 996 6768, E-mail jvillano@uic.edu

  Article Information

Published online: February 8, 2008
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 12