The Cause of Chiari II Malformation: A Unified Theory

Vol. 15, No. 1, 1989

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Original Paper

The Cause of Chiari II Malformation: A Unified Theory
David G. McLone, Paul A. Knepper

Division of Pediatric Neurosurgery, The Laboratory for Oculo-Cerebrospinal Investigation, The Children's Memorial Medical Center and Northwestern University Medical School, Chicago, Ill., USA

Address of Corresponding Author

Pediatr Neurosci 1989;15:1-12 (DOI: 10.1159/000120432)

Key Words

Developmental neurobiology
Chiari II malformation
Hydrocephalus
Microscopy
Neural tube defects

Abstract

The cause of the Chiari II hindbrain deformity in children born with a myelomeningocele can be explained by the lack of distention of the embryonic ventricular system. Defective occlusion and an open neural tube precludes the accumulation of fluid and pressure within the cranial vesicles. This distention is critical to normal brain development. The small posterior fossa, cerebral disorganization, and lückenschädel are the result.

Author Contacts

David G. McLone, MD, PhD, Division of Pediatric Neurosurgery, Children's Memorial Medical Center, 2300 Children's Plaza, Chicago, IL 60614 (USA)

Article Information

Published online: March 05, 2008
Number of Print Pages : 12

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