Relation of Chronic Obstructive Pulmonary Disease Exacerbations to FEV<sub>1</sub> – An Intricate Tango

Vol. 77, No. 2, 2009

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Relation of Chronic Obstructive Pulmonary Disease Exacerbations to FEV₁ - An Intricate Tango
Dennis E. Niewoehner

Pulmonary and Critical Care Section, Veterans Administration Medical Center and University of Minnesota, Minneapolis, Minn., USA

Address of Corresponding Author

Respiration 2009;77:229-235 (DOI: 10.1159/000162877)

Key Words

Chronic obstructive pulmonary disease
Lung function
Exacerbation

Abstract

This article provides a brief review of the complex interrelationships that surround chronic obstructive pulmonary disease exacerbations and lung function, particularly FEV₁. Areas of discussion include a consideration of baseline lung function as a risk factor for exacerbation, the magnitude and duration of lung function abnormalities after onset and during recovery from exacerbations, the relation between changes in lung function during an exacerbations and clinical outcomes, and the potential impact of recurrent exacerbations on long-term deterioration in lung function.

Author Contacts

Dennis E. Niewoehner
Pulmonary Section (111N), Veterans Administration Medical Center
1 Veterans Drive
Minneapolis, MN 55417 (USA)
Tel. +1 612 467 4412, Fax +1 612 727 5634, E-Mail niewo001@umn.edu

Article Information

Received: March 31, 2008
Accepted after revision: July 4, 2008
Published online: October 7, 2008
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 1, Number of References : 33

Medline Abstract (ID 18840996)

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