Cytokines and Glomerular Injury

Vol. 19, No. 5, 1996

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Mechanisms of Glomerular Diseases

Cytokines and Glomerular Injury
Tammo Ostendorf, Michael Burg, Jürgen Floege

Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany

Address of Corresponding Author

Kidney Blood Press Res 1996;19:281-289 (DOI: 10.1159/000174088)

Key Words

Cytokines
Extracellular matrix
Glomerulonephritis
Glomerulus
Growth factors
Mesangium

Abstract

Since reports of the first data on cytokines in renal diseases about 10 years ago, the field has seen an explosive growth over the last decade. It is now realized that cytokines can be synthesized by many different types of cells, including glomerular cells, upon adequate stimulation and exert a wide range of actions mostly in an autocrine or paracrine fashion. Cytokines not only contribute to developmental processes, but also to the maintenance of normal tissue integrity and in particular to the initiation and modulation of tissue injury, healing, or scarring. This review summarizes some recent data on the role of cytokines in glomerular disease and describes some of the first experimental approaches to therapeutically interfere with cytokine actions.

Author Contacts

Jürgen Floege, MD, Division of Nephrology 6840, Medical School, D-30623 Hannover (Germany)

Article Information

Accepted: August 5, 1996
Published online: November 11, 2008
Number of Print Pages : 9

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