Paper

Renal Biopsies in Lupus nephritis
Correlation of Electron Microscopic Findings with Clinical Course
E. Grishman, J.G. Porush, S.L. Lee, J. Churg

Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York, N.Y., Division of Nephrology, Brookdale Hospital Center Brooklyn, N.Y. and Department of Medicine, Jewish Hospital and Medical Center of Brooklyn, Brooklyn, N.Y.

Address of Corresponding Author

Nephron 1973;10:25-36 (DOI: 10.1159/000180175)

  Key Words

• Systemic lupus erythematosus
• Nephritis
• Glomerular deposits
• Capillary wall
• Mesangium

  Abstract

31 patients with systemic lupus erythematosus had renal biopsies performed and were followed for up to 14 years. The biopsies were examined by light and electron microscopy. A good correlation was found between the number of electron dense deposits and the progression of renal disease. Patients with massive deposits had poorer prognosis than those with few deposits. Segmental glomerular lesions were usually associated with few deposits. Localization was also important: pure mesangial deposits indicated favorable prognosis, while subendothelial deposits had the opposite effect.

Copyright © 1973 S. Karger AG, Basel

  Author Contacts

Authors' address: Dr. E. Grishman, Dr.J.G. Porush, Dr. S.L. Lee and Dr.J. Churg, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. (USA)

  Article Information

Published online: November 27, 2008
Number of Print Pages : 12