Effect of Somatostatin on Fasting and Glucose-Stimulated Gastric Inhibitory Polypeptide Release in Man

Vol. 24, No. 2, 1982

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Original Paper

Effect of Somatostatin on Fasting and Glucose-Stimulated Gastric Inhibitory Polypeptide Release in Man
M. Salera^a, L. Pironi^a, P. Giacomoni^a, S. Venturi^a, M. Capelli^b, M. Miglioli^a, L. Barbara^a

^aClinica Medica III, University of Bologna;
^bLaboratorio Centralizzato, Policlinico S. Orsola, Bologna, Italy

Address of Corresponding Author

Digestion 1982;24:126-132 (DOI: 10.1159/000198787)

Key Words

Gastric inhibitory polypeptide
Insulin
Somatostatin

Abstract

The effect of intravenous somatostatin infusion on circulating gastric inhibitory polypeptide (GIP), insulin, glucagon and on blood glucose was investigated in 7 healthy volunteers in the fasting state and during the oral ingestion of 75 g glucose. Somatostatin (1.1 µg/kg/h) infused 30 min before and continued 60 min after the ingestion of glucose did not affect fasting levels of any of the above parameters while it significantly suppressed the GIP and insulin response to glucose. The same somatostatin dose infused 30 min after the ingestion of glucose decreased significantly the raised levels of GIP and insulin and further increased blood glucose levels. It is concluded that somatostatin inhibits GIP release mainly at the level of the GIP-producing cells.

Author Contacts

Dr. Marcello Salera, Clinica Medica III, Policlinico S. Orsola, via Massarenti 9, Bologna (Italy)

Article Information

Received: January 13, 1982
Received in revised form: March 12, 1982
Published online: January 28, 2009
Number of Print Pages : 7

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