Slow Infusion of Vincristine in the Treatment of Refractory Thrombocytopenic Purpura

Vol. 80, No. 3, 1988

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Slow Infusion of Vincristine in the Treatment of Refractory Thrombocytopenic Purpura
M. Linares, A. Cervero, M. Sanchez, S. Garcia, A. Miguel-Sosa, A. Miguel-Garcia, J.M. Miguel-Borja

Hospital General de Valencia, Servicio de Hematología, Valencia, España

Address of Corresponding Author

Acta Haematol 1988;80:173-174 (DOI: 10.1159/000205627)

Key Words

Idiopathic thrombocytopenic purpura
Slow-infusion vincristine
Vincristine

Abstract

Eight patients with idiopathic thrombocytopenic purpura (ITP), who were refractory to glucocorticoid therapy, were given slow infusions of vincristine (VCR) over a 4- to 6-hour period at weekly intervals for 4 weeks. Three patients showed a return to normal platelet counts maintained for 3 months or longer. A transient recovery was observed in 1 patient and a partial response was observed in 3 patients. All patients tolerated therapy well, without side effects. In conclusion, therapy with slow infusion of VCR can be effective in refractory ITP.

Author Contacts

Dr. Mariano Linares, Servicio de Hematología, Hospital General de Valencia, Avenida Tres Cruces s.n., E-46008 Valencia (Spain)

Article Information

Received: November 27, 1987
Accepted: April 26, 1988
Published online: February 24, 2009
Number of Print Pages : 2

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