Paraproteinemic Variety of Pure Red Cell Aplasia

Vol. 60, No. 4, 1978

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Paraproteinemic Variety of Pure Red Cell Aplasia
Immunological Studies in 1 Patient
L. Resegotti, C. Dolci, G. Palestro, C. Peschle

Ospedale Maggiore SS. Annunziata, Savigliano; Institute of Pathology, University of Turin, Turin and Institute of Medical Pathology and ICHO, IInd Faculty, University of Naples, Naples

Address of Corresponding Author

Acta Haematol 1978;60:227-232 (DOI: 10.1159/000207718)

Key Words

PRCA
PRCA and paraproteinemia
IgG inhibitor to erythropoiesis
Serum M component
Lymphocyte markers

Abstract

A case of adult pure red cell aplasia (PRCA) with a serum IgG inhibitor to erythropoiesis and an IgG M component is presented. The study of lymphocyte populations revealed a slight but definite decrease of E and EA rosettes, with dissociation between E rosettes and PHA blastic transformation of blood lymphocytes and increase of membrane IgM-bearing lymphocytes. The relationship between PRCA and paraproteinemia is discussed: it is suggested that the serum M component may derive from an immunological unbalance between T and B lymphocytes. Since a survey of the literature reveals 5 similar cases, it is suggested that paraproteinemia may be the hallmark of a particular variety of chronic PRCA 'type 1'.

Author Contacts

Dr.L. Luigi Resegotti, Divisione di Medicina Generale,, Ospedale Maggiore SS. Annunziata, Via Ospedali, 14-12038 Savigliano (CN) (Italy)

Article Information

Received: October 4, 1977
Accepted: January 6, 1978
Published online: March 03, 2009
Number of Print Pages : 6

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