Susceptibility to Insulin Resistance after Kidney Donation: A Pilot Observational Study

Vol. 30, No. 4, 2009

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Original Report: Patient-Oriented, Translational Research

Susceptibility to Insulin Resistance after Kidney Donation: A Pilot Observational Study
Walid Shehab-Eldin^{a, b}, Sabry Shoeb^b, Said Khamis^b, Yassien Salah^b, Ahmed Shoker^a

^aRoyal University Hospital, Department of Medicine, Division of Nephrology, University of Saskatchewan, Saskatoon, Sask., Canada;
^bInternal Medicine Department, Faculty of Medicine, Menoufya University, Cairo, Egypt

Address of Corresponding Author

Am J Nephrol 2009;30:371-376 (DOI: 10.1159/000232577)

Key Words

Insulin resistance
Kidney donors

Abstract

Background: In chronic kidney disease the contribution of decreased glomerular filtration rate (GFR) versus enhanced inflammation to cause insulin resistance (IR) is controversial. Aim: This pilot observational study examines, therefore, the prevalence of IR after kidney donation and factors that may determine its level. Methods: Insulin, proinsulin, adiponectin, malondialdehyde, and hsCRP were measured by conventional techniques in 14 previous kidney donors and 25 healthy volunteers. Results: Estimated GFR from Cockcroft-Gault formula of 76.42 ± 19.39 ml/min/1.73 m² in the nephrectomized group was significantly lower (p < 0.01) than that in the control group of 125 ± 32.9 ml/min/1.73 m². Fasting serum insulin of 16.57 ± 16.86 mU/l and homeostasis model assessment of insulin resistance (HOMA-IR) of 4.86 ± 5.11 in the nephrectomized group were significantly higher (p < 0.01) than the insulin level of 6.02 ± 4.06 mU/l and HOMA-IR of 1.5 ± 1.06 in the control group. There was no significant difference in levels in inflammatory mediators between the two groups. None of the tested inflammatory mediators correlated significantly with IR. Conclusion: Reduced GFR alone in previous kidney donors is associated with increased IR.

Author Contacts

Ahmed Shoker, MD, FRCPC
Department of Medicine, Division of Nephrology, University of Saskatchewan
103 Hospital Drive, Saskatoon, Sask. S7N 0W8 (Canada)
Tel. +1 306 966 2630, Fax +1 306 966 7996
E-Mail ass787@mail.usask.ca

Article Information

Received: March 12, 2009
Accepted: June 10, 2009
Published online: July 31, 2009
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 22

Medline Abstract (ID 19648735)

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