SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective

Vol. 68, No. 2, 2007

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SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective
P. Ferré^{a, b}, F. Foufelle^{a, b}

^aInserm, UMR S 671, Centre de Recherches Biomédicales des Cordeliers,
^bUniversité Pierre et Marie Curie-Paris 6, UMR S 671, Paris, France

Address of Corresponding Author

Horm Res 2007;68:72-82 (DOI: 10.1159/000100426)

Key Words

Sterol regulatory element binding protein-1c
Insulin
Lipogenesis
Endoplasmic reticulum
Diabetes
Obesity

Abstract

Insulin has long-term effects on glucose and lipid metabolism through its control on the expression of specific genes. In insulin sensitive tissues and particularly in the liver, the transcription factor sterol regulatory element binding protein-1c (SREBP-1c) transduces the insulin signal. SREBP-1c is a transcription factor which is synthetized as a precursor in the membranes of the endoplasmic reticulum and which requires post-translational modification to yield its transcriptionally active nuclear form. Insulin activates the transcription and the proteolytic maturation of SREBP-1c. SREBP-1c induces the expression of a family of genes involved in glucose utilization and fatty acid synthesis and can be considered as a thrifty gene. Since a high lipid availability is deleterious for insulin sensitivity and secretion, a role for SREBP-1c in dyslipidaemia and type 2 diabetes has been considered in genetic studies and some association demonstrated. Finally, SREBP-1c could also participate to the hepatic steatosis observed in humans and related to alcohol consumption and hyperhomocysteinaemia, two pathologies which are concomitant with a stress of the endoplasmic reticulum and an insulin-independent SREBP-1c activation.

Author Contacts

P. Ferré
Inserm, UMR S 671, Centre de Recherches Biomédicales des Cordeliers
15 rue de l'Ecole de médecine
FR-75270 Paris Cedex 06 (France)
Tel. +33 1 42 34 69 24, Fax +33 1 40 51 85 86, E-Mail pferre@bhdc.jussieu.fr

Article Information

Published online: March 5, 2007
Number of Print Pages : 11
Number of Figures : 3, Number of Tables : 0, Number of References : 90

Medline Abstract (ID 17344645)

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