Paper

The Glomerular Transcriptome and Proteome
Christer Betsholtz^{a, b}, Liqun He^a, Minoru Takemoto^{a, c}, Jenny Norlin^a, Ying Sun^a, Jaakko Patrakka^a, Karl Tryggvason<sup>a

a</sup>Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, and
^bDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden;
^cDepartment of Clinical Cell Biology and Medicine, Chiba University, Chuo-ku, Japan

Address of Corresponding Author

Nephron Exp Nephrol 2007;106:e32-e36 (DOI: 10.1159/000101790)

  Key Words

• Glomerulus
• Podocyte
• Microarray
• Transcriptome
• Proteome

  Abstract

Histopathology provides the current basis for classification and diagnosis of glomerular disorders. Molecular profiling methods, such as microarray analysis of mRNA expression, have rapidly emerged over the past years and are now applicable to minute amounts of tissue material, such as glomeruli from embryos or adult experimental animals, or from human renal needle biopsies. This review summarizes current efforts aiming at the determination of the glomerular transcriptome and proteome during development, in the healthy adult, and in disease. These studies are encouraging and show that comprehensive molecular profiling of the kidney glomerulus will most likely provide significant new insights into the normal structure and function of the glomerular filter, the molecular mechanisms of glomerular development, the diagnosis and classification of glomerular disease, and the pathogenic mechanisms underlying the stepwise breakdown of glomerular filter function that accompanies several common systemic disorders.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Christer Betsholtz
Laboratory of Vascular Biology, Hus A3, Plan 4, Division of Matrix Biology
Department of Medical Biochemistry and Biophysics, MBB, Scheeles väg 2
Karolinska Institutet, SE-171 77 Stockholm (Sweden)
Tel. +46 8 5248 7960, Fax +46 8 313 445, E-Mail christer.betsholtz@ki.se

  Article Information

Published online: June 6, 2007
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 0, Number of References : 21