In-Depth Topic Review

Proteinuria as a Therapeutic Target in Patients with Chronic Kidney Disease
Biff F. Palmer

Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical School, Dallas, Tex., USA

Address of Corresponding Author

Am J Nephrol 2007;27:287-293 (DOI: 10.1159/000101958)

  Key Words

• Proteinuria, targeting
• Chronic kidney disease
• Antiproteinuric therapy

  Abstract

Patients excreting large amounts of urinary protein, who are otherwise deemed to be optimally treated, should still be considered at high risk for renal disease progression. The observation that reductions in urinary protein excretion, in a graded fashion over a relatively short period of time, correlate with long-term preservation of renal function supports the idea of using urinary protein excretion as a guide to implementation of renoprotective therapies. The association between residual proteinuria and renal outcomes suggests that minimization of proteinuria is an important therapeutic goal in the management of proteinuric chronic kidney disease patients. This article reviews the evidence for using proteinuria as a target for the implementation of therapies shown to have renal protective effects.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Biff F. Palmer, MD
Department of Medicine, Division of Nephrology
University of Texas Southwestern Medical School
5323 Harry Hines Blvd., Dallas, TX 75390-8856 (USA)
Tel. +1 214 648 7848, Fax +1 214 648 2071, E-Mail biff.palmer@utsouthwestern.edu

  Article Information

Received: March 25, 2007
Accepted: March 26, 2007
Published online: April 23, 2007
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 48