Original Paper

Effect of Thalidomide on Endostatin Levels in Retinal Ischemia/Reperfusion Injury
Semih Aydoan^a, Peykan Türkçüolu^a, Ülkü Çeliker^a, Nevin lhan^b

Departments of
^aOphthalmology and
^bBiochemistry, Frat University School of Medicine, Elaz, Turkey

Address of Corresponding Author

Ophthalmologica 2007;221:418-420 (DOI: 10.1159/000107503)

  Key Words

• Thalidomide
• Endostatin
• Retinal ischemia/reperfusion injury

  Abstract

Aim: To evaluate the effects of thalidomide treatment on endostatin production in ischemia/reperfusion-injured guinea pigs retinas. Methods: Control, ischemia, thalidomide/ischemia groups including 7 animals in each were formed from pigmented male guinea pigs. Retinal ischemia was induced by cannulating anterior chambers and lifting the bottle to a height of 205 cm for 90 min in the ischemia and thalidomide/ischemia groups. The thalidomide/ischemia group received thalidomide (300 mg/kg/day) via nasogastric tube 24 h before ischemia and during 7 days of reperfusion. Guinea pigs were scarified for biochemical analysis of retinal endostatin level by ELISA. Results: The mean retinal endostatin levels of the control, ischemia and thalidomide/ischemia groups were 11.79 ± 7.36, 14.70 ± 4.88, 30.94 ± 15.59 ng/ml, respectively. The mean retinal endostatin level of the thalidomide/ischemia group was significantly higher than that of the control group (p = 0.011). The mean retinal endostatin level of the thalidomide/ischemia group was higher than that of the ischemia group, but there was no statistically significant difference (p = 0.073). No statistically significant difference in the mean retinal endostatin level was found between the control and ischemia groups (p = 0.165). Conclusion: Thalidomide treatment increased retinal endostatin level in ischemia/reperfusion-injured guinea pig retinas.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Peykan Türkçüolu, MD
Assistant Professor of Ophthalmology
Frat University School of Medicine, Department of Ophthalmology
TR-23200 Elaz (Turkey)
Tel. +90 4242 479 334, Fax +90 4242 388 096, E-Mail peykan74@yahoo.com

  Article Information

Received: December 12, 2006
Accepted: January 29, 2007
Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 15