Original Paper

Adiponectin Is Associated with Brain Natriuretic Peptide and Left Ventricular Hypertrophy in Hemodialysis Patients with Type 2 Diabetes Mellitus
Hirotaka Komaba, Naoya Igaki, Shunsuke Goto, Kazuki Yokota, Toshiyuki Takemoto, Yoshiaki Hirosue, Takeo Goto

Department of Internal Medicine, Takasago Municipal Hospital, Takasago, Japan

Address of Corresponding Author

Nephron Clin Pract 2007;107:c103-c108 (DOI: 10.1159/000108651)

  Key Words

• Adiponectin
• Brain natriuretic peptide
• Hemodialysis
• Left ventricular hypertrophy
• Left ventricular mass index
• Type 2 diabetes mellitus
• Chronic heart failure

  Abstract

Background: Adiponectin, an adipocyte-derived hormone, has been shown to prevent the progression of left ventricular hypertrophy (LVH). However, recent studies have demonstrated increased levels of adiponectin according to the severity of chronic heart failure. We therefore investigated the relationships between adiponectin, brain natriuretic peptide (BNP), and LVH in type 2 diabetic patients on hemodialysis. Methods: The study population comprised 41 type 2 diabetic patients on hemodialysis. Left ventricular mass index (LVMI) and criteria for LVH were determined on the basis of echocardiographic findings. Serum adiponectin and plasma BNP levels were assayed with a commercially available kit. Results: Serum adiponectin levels significantly correlated with BMI (r = –0.49, p < 0.01), HDL-C (r = 0.36, p < 0.05) and TG (r = –0.49, p < 0.01). In addition, serum adiponectin levels correlated significantly and positively with plasma BNP levels (r = 0.36, p < 0.05). This relationship remained significant after adjustment for age, gender, and BMI (r = 0.34, p < 0.05). Serum adiponectin levels as well as plasma BNP levels were significantly higher than in patients without LVH (p < 0.05; p < 0.01, respectively), accompanied by a positive correlation between these levels and LVMI (r = 0.42, p < 0.01; r = 0.32, p < 0.05, respectively). Conclusion: Increased levels of adiponectin were associated with elevated BNP levels and LVH in hemodialysis patients with type 2 diabetes mellitus. It is speculated that adiponectin levels may be modulated by chronic hypervolemic state in this population.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Hirotaka Komaba, MD
Division of Nephrology and Kidney Center, Kobe University School of Medicine
7-5-2 Kusunoki-cho, Chuo-ku
Kobe 650-0017 (Japan)
Tel. +81 78 382 6500, Fax +81 78 382 6509, E-Mail hkomaba@med.kobe-u.ac.jp

  Article Information

Received: January 11, 2007
Accepted: June 14, 2007
Published online: September 21, 2007
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 28