Molecular Basis for the Regenerative Properties of a Secretion of the Mollusk <i>Cryptomphalus aspersa</i>

Vol. 21, No. 1, 2008

Free Abstract Article (References) Article (PDF 466 KB)

Original Paper

Molecular Basis for the Regenerative Properties of a Secretion of the Mollusk Cryptomphalus aspersa
A. Brieva^a, N. Philips^c, R. Tejedor^b, A. Guerrero^a, J.P. Pivel^a, J.L. Alonso-Lebrero^a, S. Gonzalez^d

^aR&D Department, IFC SA, and
^bHospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain;
^cDepartment of Biological Sciences, School of Natural Sciences, Fairleigh Dickinson University, Teaneck, N.J., and
^dDermatology Service, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

Address of Corresponding Author

Skin Pharmacol Physiol 2008;21:15-22 (DOI: 10.1159/000109084)

Key Words

Cryptomphalus aspersa
C. aspersa, cellular and molecular effects
Extracellular matrix assembly
Mollusk
SCA, regenerative properties
Skin aging

Abstract

A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue.

Author Contacts

Salvador Gonzalez
Memorial Sloan-Kettering Cancer Center
160 East 53rd Street, New York, NY 10022 (USA)
Tel. +1 212 610 0185, Fax +1 212 308 0530
E-Mail gonzals6@mskcc.org

Article Information

Received: March 9, 2007
Accepted after revision: June 30, 2007
Published online: October 2, 2007
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 0, Number of References : 25

Medline Abstract (ID 17912020)

Download Citation

This journal is part of the fourth subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.