Type 2 Diabetes in Children and Adolescents in a 2-Year Follow-Up: Insufficient Adherence to Diabetes Centers

Vol. 69, No. 2, 2008

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Original Paper

Type 2 Diabetes in Children and Adolescents in a 2-Year Follow-Up: Insufficient Adherence to Diabetes Centers
Thomas Reinehr, Edith Schober, Christian L. Roth, Susanna Wiegand, Reinhard Holl, on behalf of the DPV-Wiss Study Group

Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

Address of Corresponding Author

Horm Res 2008;69:107-113 (DOI: 10.1159/000111814)

Key Words

Diabetes type 2, children
Drugs, diabetes type 2
Comorbidity, diabetes type 2

Abstract

Background/Aims: To study the 2-year course of children and adolescents with type 2 diabetes mellitus (T2DM) in general practice to present (1) the treatment modalities, (2) patient adherence, and (3) the occurrence of comorbidities. Methods: HBA1c, lipids, blood pressure, treatment modalities, occurrence of retinopathy and nephropathy were analyzed in 129 children and adolescents with T2DM (median age 13.4 years, 75% female) in specialized diabetes centers in Germany. Results: Seventy-eight (60%) children dropped out of care after a mean of 7.1 months. Drug treatment was not stopped in any of the 64 children initially treated with antidiabetic drugs. Sixteen (12%) children were treated solely by lifestyle intervention over the 2-year course. In the 51 children with complete follow-up, median HbA1c was 7.7% at diagnosis and 6.3% after 2 years. Less than 5% of all children were treated with antihypertensive or lipid-lowering drugs, while 65% suffered from hypertension and 44% from dyslipidemia. Over the course of the disease, retinopathy was not observed, while microalbuminuria occurred in 25%. Conclusions: In general practice, many children and adolescents with T2DM were lost of follow-up. Lifestyle intervention as sole treatment was not often useful for long-term metabolic control. Dyslipidemia and hypertension were seldom treated as recommended.

Author Contacts

PD Dr. Thomas Reinehr
Vestische Hospital for Children and Adolescents
University of Witten/Herdecke, Dr. F. Steiner Strasse 5
DE-45711 Datteln (Germany)
Tel. +49 2363 975 229, Fax +49 2363 975 218, E-Mail T.Reinehr@kinderklinik-datteln.de

Article Information

Received: November 13, 2006
Accepted: April 11, 2007
Published online: December 5, 2007
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 24

Medline Abstract (ID 18059091)

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