New Insights into Growth Hormone Receptor Function and Clinical Implications

Vol. 69, No. 3, 2008

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New Insights into Growth Hormone Receptor Function and Clinical Implications
A.M. Lichanska, M.J. Waters

^aSchool of Dentistry, University of Queensland, Brisbane and
^bInstitute for Molecular Bioscience and School of Biomedical Science, St. Lucia, Australia

Address of Corresponding Author

Horm Res 2008;69:138-145 (DOI: 10.1159/000112586)

Key Words

Growth Hormone
Metabolism
Receptor activation
STAT5

Abstract

Although used as a therapeutic for 50 years, it is only recently that the application of molecular techniques has provided a basis for understanding growth hormone's (GH) clinical actions. This article reviews progress in our current knowledge of the molecular mechanism of growth hormone (GH) receptor activation based on a number of physicochemical techniques, and documents insights gained into the means used by the activated GH receptor to control the expression of genes regulating growth and metabolism. These findings are related to disorders of short stature, and the therapeutic consequences are summarized.

Author Contacts

Prof. Michael Waters
Institute for Molecular Bioscience and School of Biomedical Science
St. Lucia 4072 (Australia)
Tel. +61 7 3346 2037, Fax +61 7 3346 2101
E-Mail m.waters@imb.ug.edu.au

Article Information

Received: October 26, 2006
Accepted: July 30, 2007
Published online: January 8, 2008
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 1, Number of References : 33

Medline Abstract (ID 18219216)

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