Mini Review

Advances in the Management of Paediatric Cushing's Disease
Martin O. Savage, Li F. Chan, Farhad Afshar, P. Nicholas Plowman, Ashley B. Grossman, Helen L. Storr

Departments of Endocrinology, Neurosurgery and Radiotherapy, Barts and the London School of Medicine and Dentistry, London, UK

Address of Corresponding Author

Horm Res 2008;69:327-333 (DOI: 10.1159/000117388)

  Key Words

• Cushing's disease
• Paediatrics
• Transsphenoidal surgery
• Pituitary radiotherapy

  Abstract

Cushing's disease (CD) is rare in the paediatric age range, but may present a difficult therapeutic challenge. Most paediatric endocrinologists have limited experience managing children or adolescents with CD and thus benefit from close consultation with adult colleagues. Prior to definitive treatment, a diagnostic protocol for investigation is required which broadly follows the model for adult patients. Treatment strategies for CD are described and critically appraised. The management of paediatric CD patients after cure also presents challenges for optimizing growth, bone health, reproduction and body composition from childhood into and during adult life.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Prof. Martin Savage, Department of Endocrinology
Barts and the London School of Medicine and Dentistry
John Vane Science Centre, Charterhouse Square
London EC1M 6BQ (UK)
Tel. +44 20 7882 6233, Fax +44 7882 6234, E-Mail m.o.savage@qmul.ac.uk

  Article Information

Received: March 5, 2007
Accepted: October 2, 2007
Published online: March 17, 2008
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 3, Number of References : 49