In-Depth Topic Review

The Effect of Lipoproteins on the Development and Progression of Renal Disease
Lorien S. Dalrymple^a, George A. Kaysen^a-c

Departments of
^aMedicine, and
^bBiochemistry and Molecular Medicine, University of California, Davis, and
^cDepartment of Medicine, Department of Veterans Affairs Northern California Health Care System, Sacramento, Calif., USA

Address of Corresponding Author

Am J Nephrol 2008;28:723-731 (DOI: 10.1159/000127980)

  Key Words

• Lipids
• Chronic kidney disease
• Nephropathy, progression
• Statins

  Abstract

The field of research examining how lipoproteins may contribute to the development and/or progression of renal disease has rapidly expanded over the last 25 years. In animal models, lipoproteins and lipids have been associated with both the initiation and progression of renal disease. Numerous potential mechanisms of lipoprotein-induced renal injury have been identified by utilizing animal models and tissue-culture experiments. However, with the exception of rare genetic mutations, the association between lipoproteins and human renal disease is less clear. In humans, the evidence that lipid-lowering therapy delays renal progression is limited. The purpose of this paper is to review the current literature on lipoprotein abnormalities and the development or progression of renal disease.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Lorien Dalrymple, MD, MPH
University of California, Davis
4150 V Street, Suite 3500
Sacramento, CA 95817 (USA)
Tel. +1 916 734 3774, Fax +1 916 734 7920, E-Mail lorien.dalrymple@ucdmc.ucdavis.edu

  Article Information

Received: November 24, 2007
Accepted: February 28, 2008
Published online: April 24, 2008
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 0, Number of References : 64