Review

Use of ³¹P Magnetic Resonance Spectroscopy to Study the Effect of Cortical Magnesium and Energy Metabolism after Subarachnoid Hemorrhage
Heping Yang^a, Xiangqi Tang^a, Lihua Tan^b, Liuwang Zeng^a, Zhiping Hu^a

Departments of
^aNeurology, and
^bRadiology, Second Xiangya Hospital, Central South University, Changsha, China

Address of Corresponding Author

Cerebrovasc Dis 2008;26:223-230 (DOI: 10.1159/000147448)

  Key Words

• Energy metabolism
• Magnetic resonance spectroscopy
• Subarachnoid hemorrhage
• Magnesium

  Abstract

Background: Flow metabolism coupling ensures adequate cerebral oxygenation. When subarachnoid hemorrhage (SAH) occurs, the flow metabolism coupling lost its balance and results in cerebral ischemia and infarction second to cortical magnesium and energy metabolism alternation. During chronic vasospasm, change in cortical energy metabolism is coupled with change in cerebral blood flow after SAH. Methods: What kind of noninvasive technique can be used to directly investigate the biochemical environment in the SAH brain? Studies showed that ³¹P magnetic resonance spectroscopy (³¹P MRS) is ideally suited to evaluate the pathophysiology of SAH, especially for cortical magnesium and energy metabolism. Results: The results showed that cortical magnesium and energy metabolism were significantly decreased in both animal models and human beings after SAH by using ³¹P MRS, which is associated with the severity and outcome of SAH, especially after aneurysmal SAH. Conclusion: ³¹P MRS data, combined with other MRI sequences, provide a comprehensive assessment of both structural and functional deficits and a guidance on clinical therapy for SAH.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Prof. Zhiping Hu, MD, PhD
Department of Neurology, Second Xiangya Hospital
Central South University
Changsha, Hunan, 410011 (China)
Tel. +86 138 0845 0901, Fax +86 731 5533 525, E-Mail huzhipingxy@yahoo.com.cn

  Article Information

Received: September 3, 2007
Accepted: February 7, 2008
Published online: July 23, 2008
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 1, Number of References : 30