Original Paper

Initiation of Glucose-Based Peritoneal Dialysis Is Associated with Increased Prevalence of Metabolic Syndrome in Non-Diabetic Patients with End-Stage Renal Disease
Na Jiang^a, Jiaqi Qian^a, Aiwu Lin^a, Bengt Lindholm^b, Jonas Axelsson^b, Qiang Yao<sup>a

a</sup>Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Center for Peritoneal Dialysis Research, Shanghai, PR China;
^bDivisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden

Address of Corresponding Author

Blood Purif 2008;26:423-428 (DOI: 10.1159/000153248)

  Key Words

• Chronic kidney disease
• Dyslipidemia
• Body mass index
• Hyperglycemia
• Glucose exposure

  Abstract

Background: Glucose-based peritoneal dialysis (PD) is the original PD form. However, glucose uptake from the peritoneal cavity may contribute to dysmetabolism. Methods: We retrospectively assessed metabolic syndrome (MS) and its components in 195 non-diabetic incident PD patients at baseline and after 34.3 (20.5-60.0) months of PD. MS was defined according to the Adult Treatment Panel III criteria. Results: While 22.1% of the patients met MS criteria at baseline, 69.2% (p < 0.01) exhibited MS during PD. MS burden increased significantly after PD (p < 0.01). The disorder BMI and lipids, and MS components number, correlated with peritoneal glucose exposure and PD duration (p < 0.05). In Cox analysis, age, BMI, triglyceride, C-reactive protein (CRP) and glucose exposure were all independently associated with MS development. Conclusions: PD commencement in end-stage renal disease patients was associated with an increased MS prevalence. High glucose exposure and long PD duration were associated with MS existence, along with old age, high BMI, triglyceride and CRP.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Qiang Yao, MD, PhD
Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai Center for Peritoneal Dialysis Research
145 Shandong Zhong Road, Shanghai 200001 (PR China)
Tel. +86 21 5388 2014, Fax +86 21 6326 0745, E-Mail yaoqiang_rj@yahoo.com.cn

  Article Information

Dr. Qiang Yao is currently the Associate Medical Director of Baxter Renal, Asia Pacific.

Received: March 28, 2008
Accepted: June 26, 2008
Published online: September 6, 2008
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 4, Number of References : 29