Inheritance of Human Muscle Enzyme Adaptation to Isokinetic Strength Training

Vol. 36, No. 6, 1986

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Original Paper

Inheritance of Human Muscle Enzyme Adaptation to Isokinetic Strength Training
Marie-Christine Thibault^a, Jean-Aimé Símoneau^b, Claude Côté^a, Marcel R. Boulay^b, Pierre Lagassé^b, Martine Marcotte^b, Claude Bouchard^b

^aSchool of Medicine, and
^bPhysical Activity Sciences Laboratory, Laval University, Québec, Canada

Address of Corresponding Author

Hum Hered 1986;36:341-347 (DOI: 10.1159/000153657)

Key Words

Genotype-training interaction
Isokinetic strength training
Twins
Muscle enzyme activities
Sensitivity to chronic training

Abstract

Five monozygotic twin pairs were submitted to a 10-week isokinetic strength training program and biochemical characteristics measured before and after training to determine the role of heredity in skeletal muscle adaptation, while 5 unrelated sedentary subjects served as control group. Experimental subjects performed twice 3 series of 5 bilateral reciprocal alternating knee flexions and extensions at a velocity of 90 °/s 5 times per week. Before and after the training period, for each subject, the peak muscular torque output was measured at the same velocity and the vastus lateralis muscle was biopsied for biochemical determinations. No significant change was observed in the control group. Training increased peak muscular torque output by 24%. The activities of hexokinase, malate dehydrogenase and 3-hydroxyacyl CoA dehydrogenase also increased significantly by 28, 26 and 38%, respectively. Interindividual variations in the response of these variables to training were noted but these were shown to be independent of the genotype. No overall effect of training was observed for oxoglutarate dehydrogenase activity (OGDH). However, changes were seen in individual pairs of twins and these were in opposite directions in some pairs compared to others, thus explaining the absence of a general training effect. Significant intrapair resemblance in the training response was present for OGDH (r = 0.76), indicating that the sensitivity to isokinetic strength training for OGDH was highly variable, not random and probably genetically determined.

Author Contacts

Claude Bouchard, PhD, Physical Activity Sciences Laboratory, PEPS, Laval University, Ste-Foy, Québec, G1K 7P4 (Canada)

Article Information

Published online: September 02, 2008
Number of Print Pages : 7

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