Alpha-1-Antitrypsin Deficiency and Liver Disease

Vol. 12, No. 3, 1994

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Paper

Alpha-1-Antitrypsin Deficiency and Liver Disease
Theresa Propst^a, Albert Propst^a, Otto Dietze^b, Gerd Judmaier^a, Herbert Braunsteiner^a, Wolfgang Vogel^a

Departments of
^aInternal Medicine and
^bPathology, Innsbruck University, Innsbruck, Austria

Address of Corresponding Author

Dig Dis 1994;12:139-149 (DOI: 10.1159/000171447)

Key Words

Alpha- 1-antitrypsin deficiency
Liver disease

Abstract

Alpha-1-antitrypsin deficiency is a common autosomal recessive disorder associated with premature development of emphysema, liver cirrhosis and hepatocellular carcinoma. This article reviews the existing literature on alpha-1-antitrypsin deficiency, with an emphasis on recent developments. A description of the protein, gene structure and function of alpha-1-antitrypsin as well as clinical aspects are presented. Treatment issues are addressed and a framework for the diagnostic workup and management of patients with alpha-1-antitrypsin deficiency and chronic liver disease is provided.

Author Contacts

Theresa Propst, MD, Department of Internal Medicine, Innsbruck University, Anichstrasse 35, A-6020 Innsbruck (Austria)

Article Information

Published online: November 04, 2008
Number of Print Pages : 11

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