Hypothalamic Sarcoidosis and Hypopituitarism

Vol. 12, No. 1, 1980

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Original Paper

Hypothalamic Sarcoidosis and Hypopituitarism
Husain Jawadi, Thomas J. Hanson, Janet E. Schemmel, Paul Beck, Fred H. Katz

Division of Endocrinology, Department of Internal Medicine, University of Colorado Medical Center, Denver, Colo.

Address of Corresponding Author

Horm Res 1980;12:1-9 (DOI: 10.1159/000179099)

Key Words

Hypothalamus
Sarcoidosis
Hypothalamic releasing hormones
Computerized tomography of hypothalamus
Hypothalamic hypothyroidism

Abstract

4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.

Author Contacts

M. Husain Jawadi, MD, Veterans Administration Hospital, 5500 East Kellogg, Wichita, KS 67218 (USA)

Article Information

Received: April 20, 1979
Revised: July 19, 1979
Accepted: July 23, 1979
Published online: November 25, 2008
Number of Print Pages : 9

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