Original Paper

Membranous Nephropathy: Predictors of Terminal Renal Failure
Wu-Hao Tu, Diana B. Petitti, Claude G. Biava, Özden Tulunay, James Hopper, Jr.

Departments of Medicine and Medical Methods Research, Kaiser-Permanente Medical Care Program, Oakland, Calif., and Departments of Medicine and Pathology, University of California Medical Center, San Francisco, Calif., USA

Address of Corresponding Author

Nephron 1984;36:118-124 (DOI: 10.1159/000183130)

  Key Words

• Membranous nephropathy
• Renal failure, terminal
• Prednisone treatment

  Abstract

By univariate analysis of patients with membranous nephropathy, terminal renal failure was associated with male sex, a large amount of proteinuria, low serum albumin concentration, low creatinine clearance rate, high serum creatinine concentration, and high systolic blood pressure, but was not associated with age or prednisone treatment. In a multivariate life table analysis that controlled for all these factors simultaneously, the risk of developing terminal renal failure was significantly independently associated only with sex, serum albumin concentration, and prednisone treatment, being higher in men, lower in those treated with prednisone, and inversely related to serum albumin. Except for the minimal electron-dense deposition, the electron microscopic findings had no predictive value.

Copyright © 1984 S. Karger AG, Basel

  Author Contacts

Dr. W.-H.Tu, Department of Medicine, Kaiser-Permanente Medical Center, 280 W. MacArthur Boulevard, Oakland, CA 94611 (USA)

  Article Information

Accepted: May 25, 1983
Published online: December 03, 2008
Number of Print Pages : 7