Serum Levels of Erythropoietin as a Novel Marker Reflecting the Severity of Diabetic Nephropathy

Vol. 75, No. 4, 1997

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Original Paper

Serum Levels of Erythropoietin as a Novel Marker Reflecting the Severity of Diabetic Nephropathy
S. Inomata^a,b, M. Itoh^b, H. Imai^c, T. Sato^a

^aSection of Internal Medicine and Disability Prevention, Division of Medicine, Disability Science, Tohoku University Graduate School,
^bDivision of Metabolism and Diabetes Mellitus, Akita Medical Center, and
^cThird Department of Internal Medicine, Akita University School of Medicine, Akita, Japan

Address of Corresponding Author

Nephron 1997;75:426-430 (DOI: 10.1159/000189580)

Key Words

Erythropoietin
Hemoglobin
Albumin excretion rate
Diabetic nephropathy
Interstitial fibrosis

Abstract

Erythropoietin (EPO) is reported to be mainly produced by renal peritubular interstitial cells. Serum levels of EPO may provide new information on the tubulointerstitial lesions in patients with diabetic nephropathy. We determined EPO, hemoglobin (Hb), and Hb × EPO in 63 diabetic patients who showed normo-, micro- or macroalbuminuria with normal or reduced renal function (creatinine clearance, Ccr, 60 ml/min or < 60 ml/min). In addition, we followed up Ccr during a mean of 26 months in 13 patients with overt nephropathy and normal renal function. The following results were obtained: (1) Hb, EPO, and Hb × EPO values gradually decreased along with advancing stages of nephropathy, and (2) 6 patients with rapidly decreasing renal function showed significantly lower initial EPO and Hb × EPO values than 7 patients without it (p < 0.01). We conclude that EPO and Hb × EPO values may be a new marker predicting future chronic renal failure in diabetic overt nephropathy.

Author Contacts

Shigeki Inomata, MD, Akita Medical Center, 6-17, Sensyu Kubota-machi, Akita city, Akita 010 (Japan)

Article Information

Accepted: June 20, 1996
Published online: December 19, 2008
Number of Print Pages : 5

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