Original Paper

Infected Hepatic and Renal Cysts: Differential Impact on Outcome in Autosomal Dominant Polycystic Kidney Disease
Tatsuya Suwabe^a, Yoshifumi Ubara^a, Yasushi Higa^a, Shohei Nakanishi^a, Yoko Sogawa^a, Kazufumi Nomura^a, Hiroaki Nishimura^a, Jyunichi Hoshino^a, Naoki Sawa^a, Hideyuki Katori^a, Fumi Takemoto^a, Michio Nakamura^a, Shinji Tomikawa^a, Shigeko Hara^b, Kenmei Takaichi<sup>a

a</sup>Nephrology Center, and
^bHealth Care Unit, Toranomon Hospital, Tokyo, Japan

Address of Corresponding Author

Nephron Clin Pract 2009;112:c157-c163 (DOI: 10.1159/000214211)

  Key Words

• Infected cysts
• Antibiotic therapy
• Autosomal dominant polycystic kidney disease

  Abstract

Background: Infected cysts are a frequent and serious complication of autosomal dominant polycystic kidney disease. Such infections are classified into those affecting hepatic cysts and those affecting renal cysts. The purpose of this study was to compare the clinical course of infected hepatic cysts with that of infected renal cysts in patients with autosomal dominant polycystic kidney disease. Methods: We analyzed 43 patients referred to us for additional treatment of severely infected cysts between January 2004 and December 2006. All patients who required further treatment in addition to antibiotic therapy were included. Results: Aspiration was performed in all 28 patients with infected hepatic cysts. As a result, 17 patients were cured, 4 remain under treatment, and 6 died. One patient was cured by partial hepatectomy. Among the 15 patients with renal cysts, aspiration was performed in 4 with identifiable infected cysts, while renal transcatheter arterial embolization after appropriate antibiotic therapy was performed in 11 without identifiable infected cysts. No patient developed recurrence. Conclusion: In patients with infected renal cysts, aspiration or renal transcatheter arterial embolization after appropriate antibiotic therapy was effective. Although aspiration was often effective in patients with infected hepatic cysts, a good outcome was less likely than in those with renal cysts.

Copyright © 2009 S. Karger AG, Basel

  Author Contacts

Tatsuya Suwabe, MD
Nephrology Center, Toranomon Hospital Kajigaya
1-3-1 Kajigaya, Takatsu-ku
Kawasaki-shi, Kanagawa-ken, 213-0015 (Japan)
Tel. +81 44 877 5111, Fax +81 44 877 5333, E-Mail suwabe@toranomon.gr.jp

  Article Information

Received: July 22, 2008
Accepted: December 4, 2008
Published online: April 24, 2009
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 21