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Renal Replacement Therapy for Acute Kidney Injury
Heather Fieghen^a, Ron Wald^{a, b}, Bertrand L. Jaber<sup>c

a</sup>Division of Nephrology, St. Michael's Hospital and the University of Toronto, and
^bThe Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ont., Canada;
^cDivision of Nephrology, St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, Mass., USA

Address of Corresponding Author

Nephron Clin Pract 2009;112:c222-c229 (DOI: 10.1159/000224788)

  Key Words

• Acute kidney injury
• Biomarkers
• Continuous renal replacement therapy
• Intermittent hemodialysis
• Sustained low-efficiency dialysis
• Dialysis dose

  Abstract

The treatment of established acute kidney injury (AKI) is largely supportive in nature. Renal replacement therapy remains the cornerstone of management for the minority of patients who have severe AKI. Optimization of renal replacement therapy may modulate the high mortality associated with AKI. Recent trials indicated that continuous renal replacement therapy does not confer a survival advantage as compared to intermittent hemodialysis. Furthermore, there is no evidence to support a more intensive strategy of renal replacement therapy in the setting of AKI. There is comparatively limited data regarding the ideal timing of renal replacement therapy initiation and the preferred mode of solute clearance.

Copyright © 2009 S. Karger AG, Basel

  Author Contacts

Ron Wald, MDCM, MPH
Division of Nephrology, St. Michael's Hospital
61 Queen Street East, 9th Floor
Toronto, Ont. M5C 2T2 (Canada)
Tel. +1 416 867 3703, Fax +1 416 867 3709, E-Mail waldr@smh.toronto.on.ca

  Article Information

Published online: June 16, 2009
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 3, Number of References : 47