Laboratory Investigation

Spectral Analysis of Field Potential Recordings by Deep Brain Stimulation Electrode for Localization of Subthalamic Nucleus in Patients with Parkinson's Disease
Yasushi Miyagi^{a, b}, Tsuyoshi Okamoto^a, Takato Morioka^b, Shozo Tobimatsu^c, Yoshitaka Nakanishi^a, Kazuyuki Aihara^d, Kimiaki Hashiguchi^b, Nobuya Murakami^e, Fumiaki Yoshida^b, Kazuhiro Samura^b, Shinji Nagata^b, Tomio Sasaki<sup>b

a</sup>Digital Medicine Initiative and Departments of
^bNeurosurgery and
^cClinical Neurophysiology, Graduate School of Medical Sciences, Kyushu University,
^dAihara Complexity Modeling Project, ERATO, JST, and
^eDepartment of Neurosurgery, Kaizuka Hospital, Fukuoka, Japan

Address of Corresponding Author

Stereotact Funct Neurosurg 2009;87:211-218 (DOI: 10.1159/000225974)

  Key Words

• Oscillatory synchrony
• Subthalamic nucleus
• Local field potential
• Spectral density analysis
• -Activity
• Deep brain stimulation
• Parkinson's disease

  Abstract

Aims: Spectral analysis of local field potential (LFP) recorded by deep brain stimulation (DBS) electrode around the subthalamic nucleus (STN) in patients with Parkinson's disease was performed. Methods: The borders of the STN were determined by microelectrode recording. The most eligible trajectory for the sensorimotor area of the STN was used for LFP recording while advancing the DBS electrode. Results: The low-frequency LFP power (- to -band) increased from a few millimeters above the dorsal border of the STN defined by microelectrode recording; however, the low-frequency power kept the same level beyond the ventral border of the STN. Only high -power showed close correlation to the dorsal and ventral borders of the STN. Conclusions: A spectral power analysis of LFP recording by DBS electrode helps with the final confirmation of the dorsal and ventral borders of the STN of Parkinson's disease in DBS implantation surgery.

Copyright © 2009 S. Karger AG, Basel

  Author Contacts

Yasushi Miyagi, MD, PhD
Division of Digital Patient, Digital Medicine Initiative, Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 (Japan)
Tel. +81 92 642 6693, Fax +81 92 642 6693
E-Mail yamiyagi@digital.med.kyushu-u.ac.jp

  Article Information

Published online: June 26, 2009
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 0, Number of References : 21